Additional Information
| Product Name: | USP37 Rabbit pAb |
|---|---|
| Catalog No.: | Y9762-100 |
| Also Known As: | USP37 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human USP37 (NP_065986.2). |
| Swiss Prot. #: | Q86T82 |
| Calculated MW: | 110 kDa |
| Detected MW: | 100 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Quesada V, et al. (2004) Biochem Biophys Res Commun 314, 54 - 62. 2. Huang X, et al. (2011) Mol Cell 42, 511 - 523. |
Details
USP37 is a member of the USP subfamily of DUBs. DUBs are categorized into 5 subfamilies: USP, UCH, OTU, MJD, and JAMM. USP37 antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. It deubiquitinates lysine 11-linked polyubiquitin chains, a specific ubiquitin-linkage type catalyzed by the APC/C complex.
