Additional Information
| Product Name: | USP33 Rabbit pAb |
|---|---|
| Catalog No.: | Y9722-100 |
| Also Known As: | USP33; VDU1 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-400 of human USP33 (NP_963920.1). |
| Swiss Prot. #: | Q8TEY7 |
| Calculated MW: | 106 kDa |
| Detected MW: | 106 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IF (1:50 - 1:100) IP (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Kikuno R, et al. (1999) DNA Res 6, 197 - 205. 2. Li Z, et al. (2002) J Biol Chem 277, 4656 - 4662. |
Details
USP33 is a member of the USP subfamily of DUBs. DUBs are categorized into 5 subfamilies: USP, UCH, OTU, MJD, and JAMM. USP33 is important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. It is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). USP33 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
