Additional Information
| Product Name: | USP15 Rabbit pAb |
|---|---|
| Catalog No.: | Y9552-100 |
| Also Known As: | USP15; UNPH-2; UNPH4 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 852-952 of human USP15 (NP_006304.1). |
| Swiss Prot. #: | Q9Y4E8 |
| Calculated MW: | 112 kDa |
| Detected MW: | 112 kDa |
| Applications: | WB (1:500 - 1:2,000) IF (1:50 - 1:100) IP (not tested) IHC (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Nagase T, et al. (1998) DNA Res 5, 31 - 39. 2. Inui M, et al. (2011) Nat Cell Biol 13, 1368 - 1375. |
Details
USP15 is a member of the USP subfamily of DUBs. DUBs are categorized into 5 subfamilies: USP, UCH, OTU, MJD, and JAMM. USP15 is a positive regulator of oncogenic TGF-β signaling and that USP15 deubiquitinates monoubiquitinated R-SMADs to enhance target gene promoter binding. USP15 also promotes oncogenic TGF-β signaling by opposing SMURF2-mediated ubiquitination of the type I TGF-β receptor, which facilitates receptor stabilization.
