Additional Information
| Product Name: | SENP1 Rabbit pAb |
|---|---|
| Catalog No.: | Y8502-100 |
| Also Known As: | SENP1; SuPr-2 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human SENP1 (NP_001254523.1). |
| Swiss Prot. #: | Q9P0U3 |
| Calculated MW: | 73 kDa |
| Detected MW: | 73 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IP (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Gong L, et al. (2000) J Biol Chem 275, 3355 - 3359. 2. Cheng J, et al. (2007) Cell 131, 584 - 595. |
Details
SENP1 is a member of the sentrin/SUMO-specific protease (SENP) family. SENP1 localizes to the nucleoplasm and catalyzes the release of SUMO1, SUMO2, and SUMO3 monomers from sumoylated substrates. SENP1 has been reported to be responsible for intracellular SUMO homeostasis in the control of normal cellular function. The removal of sumoylation by SENP1 from many important target proteins, such as HDAC1, HIF-1α, Stat5, p300, Elk-1, and SirT1, leads to the regulation of the related biological pathways.
