Additional Information
| Product Name: | Caspase-1 Rabbit pAb |
|---|---|
| Catalog No.: | Z1612-20 |
| Also Known As: | CASP1; ICE; IL1BC; P45; caspase-1; Caspase 1 |
| Size: | 20 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-311of human Caspase-1 |
| Swiss Prot. #: | P29466 |
| Calculated MW: | 45kDa |
| Detected MW: | 48KDa/20-25KDa |
| Applications: | WB (1:500 - 1:2,000) IP (1:50 - 1:100) IHC (1:50 - 1:200) IF (1:50 - 1:200) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Thornberry NA, et al. (1992) Nature 356, 768-774. 2. Feng Q, et al. (2004) Genomics 84, 587-591. |
Details
Caspase-1 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase 1 cleaves inflammatory cytokines such as pro-IL-1ß and interferon-γ inducing factor (IL-18) into their mature forms. Like other caspases, caspase 1 is proteolytically activated from a proenzyme to produce a tetramer of its two active subunits, p20 and p10.
