Additional Information
| Product Name: | NLRP12 Rabbit pAb |
|---|---|
| Catalog No.: | Z5732-100 |
| Also Known As: | NLRP12; CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 862-1062 of human NLRP12. |
| Swiss Prot. #: | P59046 |
| Calculated MW: | 120 kDa |
| Detected MW: | 120 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Shami PJ, et al. (2001) Brit J Haemat 112, 138 - 147. 2. Arthur JC, et al. (2007) J Immunol 179, 6291 - 6296. |
Details
NLRP12 is a member of the CATERPILLER family of cytoplasmic proteins. NLRPs are implicated in the activation of proinflammatory caspases via their involvement in multiprotein complexes called inflammasomes. NLRP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappaB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes.
