Additional Information
| Product Name: | ASC Rabbit pAb |
|---|---|
| Catalog No.: | Z5752-20 |
| Also Known As: | PYCARD; ASC; CARD5; TMS; TMS-1; TMS1; PYD and CARD domain containing; ASC / TMS1 |
| Size: | 20 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids50-195 of human ASC. |
| Swiss Prot. #: | Q9ULZ3 |
| Calculated MW: | 21kDa |
| Detected MW: | 20KDa |
| Applications: | WB (1:500 - 1:2,000) IF (1:50 - 1:200) IP (not tested) IHC (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Masumoto J, et al. (1999) J Biol Chem 274, 33835-33838. 2. Conway KE, et al. (2000) Cancer Res 60, 6236-6242. |
Details
ASC is an adaptor protein. It's a 22-kDa pro-apoptotic protein containing an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment domain (CARD). Expression of ASC/TMS1 can be induced by pro-apoptotic/inflammatory stimuli. During apoptosis ASC/TMS1 is re-distributed from the cytosol to the mitochondria and associates with mitochondrial Bax to trigger cytochrome c release and subsequent apoptosis. ASC/TMS1 has also been found to be a critical component of inflammatory signaling where it associates with and activates caspase-1 in response to pro-inflammatory signals.
