Additional Information
| Product Name: | NLRP6 Rabbit pAb |
|---|---|
| Catalog No.: | Z5722-100 |
| Also Known As: | NLRP6; AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; PAN3; PYPAF5 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human NLRP6. |
| Swiss Prot. #: | P59044 |
| Calculated MW: | 99kDa |
| Detected MW: | 99KDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Grenier JM, et al. (2002) FEBS Lett 530, 73-78. 2. Wang P, et al. (2015) Science 350, 826-830. |
Details
NLRP6 is a sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu.
