Additional Information
| Product Name: | NEDD4 Rabbit mAb |
|---|---|
| Catalog No.: | Y5840-100 |
| Also Known As: | NEDD4; NEDD4-1; RPF1 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human |
| Immunogen: | A synthesized peptide derived from human NEDD4. |
| Swiss Prot. #: | P46934 |
| Calculated MW: | 115 kDa |
| Detected MW: | 120 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Nagase T, et al. (1995) DNA Res 2, 37 - 43. 2. Harvey KF and Kumar S, (1999) Trends Cell Biol 9, 166 - 169. |
Details
NEDD4 is a HECT domain-containing E3 ubiquitin ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. A family of NEDD4-like proteins have been defined that includes nine members in humans. NEDD4 regulates a large number of membrane proteins, such as ion channels and membrane receptors, via ubiquitination and endocytosis.
