Additional Information
| Product Name: | Parkin Rabbit pAb |
|---|---|
| Catalog No.: | Y6012-100 |
| Also Known As: | PRKN; AR-JP; LPRS2; PARK2; PDJ; Parkin |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human Parkin. |
| Swiss Prot. #: | O60260 |
| Calculated MW: | 51 kDa |
| Detected MW: | 51 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IF (1:50 - 1:200) IP (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Tanner CM and Goldman SM, (1996) Neurol Clin 14, 317 - 335. 2. Imai Y, et al. (2000) J Biol Chem 275, 35661 - 35664. |
Details
Parkin is a RING domain-containing E3 ubiquitin ligase involved in proteasome-dependent degradation of proteins. Parkin is also important for mitochondrial quality control by lysosome-dependent degradation of damaged mitochondria through mitophagy.
