Additional Information
| Product Name: | IL-1 beta Rabbit pAb |
|---|---|
| Catalog No.: | Z5772-100 |
| Also Known As: | IL-1; IL1-BETA; IL1F2; IL1 beta; IL1B |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-269 of human IL1 beta. |
| Swiss Prot. #: | P01584 |
| Calculated MW: | 30kDa |
| Detected MW: | 31kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Auron PE, et al. (1984) Proc Nat Acad Sci 81, 7907-7911. 2. Dinarello CA, (1998) Int Rev Immunol 16, 457-499. |
Details
IL-1 beta is one of the major caspase-1 targets, is a multifunctional cytokine that is involved in a host of immune and proinflammatory responses. It is produced primarily by activated monocytes and macrophages. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets. Human IL-1β is synthesized as a 31 kDa precursor. To gain activity, the precursor must be cleaved by caspase-1 between Asp116 and Ala117 to yield a 17 kDa mature form.
