Additional Information
| Product Name: | AIM2 Rabbit pAb |
|---|---|
| Catalog No.: | Z5782-20 |
| Also Known As: | AIM2; PYHIN4 |
| Size: | 20 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human AIM2. |
| Swiss Prot. #: | O14862 |
| Calculated MW: | 38kDa |
| Detected MW: | 47kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. DeYoung KL, et al. (1997) Oncogene 15, 453-457. 2. Choubey D, et al. (2000) FEBS Lett 474, 38-42. |
Details
AIM2 is a member of the IFI20X /IFI16 family. It's an interferon-inducible protein containing an amino-terminal pyrin domain and carboxy-terminal HIN-200 domain that functions in innate immunity and tumor progression. AIM2 has a critical role in the activation of caspase-1, the protease responsible for the processing of pro-inflammatory cytokines IL-1β and IL-18.
