Additional Information
| Product Name: | [KO Validated] IL-18 Rabbit pAb |
|---|---|
| Catalog No.: | Z5762-100 |
| Also Known As: | IL18; IGIF; IL-18; IL-1g; IL1F4 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-193 of human IL18. |
| Swiss Prot. #: | Q14116 |
| Calculated MW: | 22kDa |
| Detected MW: | 23kDa |
| Applications: | WB (1:500 - 1:2,000) IP (1:50 - 1:100) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Okamura H, et al. (1995) Nature 378, 88-91. 2. Henao-Mejia J, et al. (2012)Nature 482, 179-185. |
Details
IL-18 belongs to the IL-1 family. It's a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells.
