Additional Information
| Product Name: | CBX4 Rabbit mAb |
|---|---|
| Catalog No.: | Y6342-100 |
| Also Known As: | CBX4; NBP16; PC2 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthesized peptide derived from human CBX4. |
| Swiss Prot. #: | O00257 |
| Calculated MW: | 61 kDa |
| Detected MW: | 61 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Satijn DPE, et al. (1997) Mol Cell Biol 17, 6076 - 6086. 2. Cao R, et al. (2005) Mol Cell 20, 845 - 854. |
Details
CBX4 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I, and its function influences EMT, DNA damage response, tumor angiogenesis, and self-renewal. CBX4 is a component of the PRC1 complex, which together with Ring1 strongly enhances the E3 ubiquitin ligase activity of the Ring2 catalytic subunit.
