Additional Information
| Product Name: | AMFR Rabbit pAb |
|---|---|
| Catalog No.: | Y6362-100 |
| Also Known As: | AMFR; GP78; RNF45 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 384-643 of human AMFR (NP_001135.3). |
| Swiss Prot. #: | Q9UKV5 |
| Calculated MW: | 72 kDa |
| Detected MW: | 72 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Watanabe H et al. (1991) J Biol Chem 266, 13442 - 13448. 2. Registre M, et al. (2004) Biochem Biophys Res Commun 320, 1316 - 1322. |
Details
AMFR is a putative seven transmembrane domain G protein-coupled receptor that functions, in part, at the cell surface as a cytokine receptor for autocrine motility factor/phosphoglucose isomerase (AMF/PGI). AMFR is also localized to an intracellular mitochondria-associated smooth ER domain where it functions as an E3 ubiquitin ligase. AMFR function, as both a cytokine receptor and ubiquitin ligase, is linked to a variety of cellular signaling cascades associated with metastasis development and increased invasiveness.
