Additional Information
| Product Name: | PYR-41 |
|---|---|
| Also Known As: | 4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester |
| Catalog No.: | F5100 |
| Size: | 5 mg |
| Molecular Weight: | 371.3 g/mol |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| Quality Assurance: | > 98% (TLC); NMR (Confirms) |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
| PDF Data Sheet: | PDF Datasheet, MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | Yang, Y., et al. (2007) Cancer Res. 67: 9472. |
Details
PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Treatment of cells with PYR-41 inhibits overall protein ubiquitination, prevents ubiquitin-mediated proteasomal degradation, and inhibits pathways mediated by the ubiquitin-proteasome. It has also been found that PYR-41 treatment increases protein sumoylation in cells.
