Additional Information
| Product Name: | P5091 |
|---|---|
| Also Known As: | 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone |
| Catalog No.: | F4110 |
| Size: | 5 mg |
| Molecular Weight: | 348.22 Da |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| Quality Assurance: | >99% by HPLC and NMR |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
| PDF Data Sheet: | PDF Datasheet, MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | (Click image to enlarge) Purity check of P5091 by HPLC |
| Shipping Method: | Room temperature shipping |
| References: | 1. Jeffrey GM, et al. (2009) IDrugs. 12(12):750–753. 2. Chauhan D, et al. (2012) Cancer Cell 22(3): 345-358. |
Details
P5091 is a cell permeable, selective and potent inhibitor of ubiquitin-specific protease 7 (USP7, IC₅₀ = 4.2 µM) and USP47. P5091(P005091) induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. It inhibits tumor growth in animal models of cancer.
How to use
In vitro: P5091 was used at 5-12 µM in various in vitro assays
In vivo: P5091 was administered through IV injection at 10 mg/kg twice weekly for 3 weeks. Images
(Click image to enlarge)
Purity check of P5091 by HPLC
In vitro: P5091 was used at 5-12 µM in various in vitro assays
In vivo: P5091 was administered through IV injection at 10 mg/kg twice weekly for 3 weeks. Images
(Click image to enlarge)
Purity check of P5091 by HPLC
