Additional Information
| Product Name: | GST-USP15 |
|---|---|
| Also Known As: | UNPH4; UNPH-2 |
| Catalog No.: | H6500 |
| Size: | 50 µg |
| Molecular Weight: | 112.4 kDa |
| Species: | Human |
| Source: | Bacterial recombinant |
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Concentration: | See tube label |
| Quality Assurance: | >70% by SDS-PAGE, see datasheet for gel image |
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| NCBI RefSeq: | NM_001252078 |
| Image(s): | Images (Click image to enlarge)  Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified GST-USP15 |
| Shipping Method: | Dry ice shipping |
| References: | 1. Reyes-Turcu FE,et al. (2009) Annu Rev Biochem 78, 363 – 397. 2. Xu M, et al. (2009) Biochem Biophys Res Commun 388, 366-371. 3. Harper S, et al. (2011) Biochemistry 50(37), 7995 – 8004. |
Details
Usp15 belongs to a family of deubiquitinating enzymes called the DU subfamily. Within this subfamily are Usp4 and Usp11 because they all contain an N-terminal “domain present in ubiquitin specific proteases” (DUSP) and ubiquitin-like (UBL) domains. Usp15 has been shown to play a role in stabilizing and activating caspase-3 during Paclitaxel-induced apoptosis. Usp15 also deubiquitinates IκBα which is an inhibitor of NF-κB.
Images
(Click image to enlarge)
Coomassie-stained SDS-PAGE
Lane 1: Molecular weight markers
Lane 2: 5 µg purified GST-USP15
Images
(Click image to enlarge)
Coomassie-stained SDS-PAGE
Lane 1: Molecular weight markers
Lane 2: 5 µg purified GST-USP15
