Additional Information
| Product Name: | GST-A20(1-365) |
|---|---|
| Also Known As: | TNFAIP3; OTUD7C; TNFA1P2 |
| Catalog No.: | H3211 |
| Size: | 100 µg |
| Molecular Weight: | 42.9 kDa without GST tag |
| Species: | Human |
| Source: | Bacterial recombinant |
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Concentration: | See tube label |
| Quality Assurance: | ~95% by SDS-PAGE, see datasheet for gel image |
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| NCBI RefSeq: | NM_006290 |
| Image(s): |  Coomassie stained SDS-PAGE |
| Shipping Method: | Dry ice shipping |
| References: | 1. Opipari AW Jr, et al. (1990) J Biol Chem 265(25), 14705 – 14708. 2. Boone DL, et al. (2004) Nat Immunol 5(10), 1052 – 1060. |
Details
Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. A20 downregulates the NF-κB pathway and proinflammatory gene expression in cells such as macrophages. The N-terminal domain of A20 contains the DUB activity.
