Additional Information
| Product Name: | RNF138 Rabbit pAb |
|---|---|
| Catalog No.: | Y6072-100 |
| Also Known As: | RNF138; HSD-4; NARF; STRIN; hNARF |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant protein of mouse RNF138. |
| Swiss Prot. #: | Q8WVD3 |
| Calculated MW: | 28 kDa |
| Detected MW: | 28 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Yamada M, et al. (2006) J Biol Chem 281, 20749 - 20760. 2. Giannini AL, et al. (2008) Biochem J 410, 101 - 111. |
Details
RNF138 is an E3 ubiquitin ligase that inactivates TCF/LEF proteins by polyubiquitination to target them for proteasome-mediated degradation. It may act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
