Additional Information
| Product Name: | RFFL Rabbit pAb |
|---|---|
| Catalog No.: | Y6432-100 |
| Also Known As: | RFFL; CARP-2; CARP2; FRING; RIFIFYLIN; RNF189; RNF34L |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RFFL (NP_001017368.1). |
| Swiss Prot. #: | Q8WZ73 |
| Calculated MW: | 40 kDa |
| Detected MW: | 50 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Coumailleau F, et al. (2004) Mol Biol Cell 15, 4444 - 4456. 2. Gan X, et al. (2012) Nat Cell Biol 14, 686 - 696. |
Details
RFFL is an E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex.
