Additional Information
| Product Name: | LRSAM1 Rabbit pAb |
|---|---|
| Catalog No.: | Y6422-100 |
| Also Known As: | LRSAM1; CMT2P; RIFLE; TAL |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human LRSAM1 (NP_612370.3). |
| Swiss Prot. #: | Q6UWE0 |
| Calculated MW: | 83 kDa |
| Detected MW: | 83 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Li B, et al. (2003) J Cell Biochem 90, 1224 - 1241. 2. Amit I, et al. (2004) Genes Dev 18, 1737 - 1752. |
Details
LRSAM1 is a multi-domain-containing E3 ubiquitin-ligase involved in the regulation of cell adhesion. The LSRAM1 protein contains amino-terminal leucine-rich repeats (LRR), an ezrin-radixin-moesin (ERM) domain, a coiled-coil region, a sterile alpha motif (SAM) domain, and a carboxy-terminal RING finger domain. Research studies demonstrate that LRSAM1 participates in the endosomal sorting of proteins by regulating the ubiquitination of Tsg101, a component of the ESCRT-I endosomal sorting complex.
