Additional Information
| Product Name: | Phospho-p53-S6 Rabbit pAb |
|---|---|
| Catalog No.: | Z4112-100 |
| Also Known As: | TP53; BCC7; LFS1; P53; TRP53; p53; TP53; BMFS5 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S6 of human p53. |
| Swiss Prot. #: | P04637 |
| Calculated MW: | 53 kDa |
| Detected MW: | 53 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Vogelstein B and Kinzler KW, (1994) Nature 370, 174 - 175. 2. Levine AJ, (1997) Cell 88, 323 - 331. 3. Knippschild U, et al. (1997) Oncogene 15, 1727 - 1736. |
Details
P53 is a tumor suppressor that plays a role in maintaining genomic stability and controlling apoptosis. During the cell cycle, it can arrest cells at the G1/S checkpoint and activate DNA repair mechanisms. It is the most mutated gene in cancer. In unstressed cells, p53 usually exists at low levels in an inactive form, being bound to Mdm2. p53 is phosphorylated at Ser6 and Ser9 by CK1δ and CK1ε both in vitro and in vivo and additionally that there may be a regulatory feedback loop involving p53 and CK1δ.
