Additional Information
| Product Name: | Phospho-p53-S392 Rabbit pAb |
|---|---|
| Catalog No.: | Z4152-20 |
| Also Known As: | TP53; BCC7; LFS1; P53; TRP53; p53; TP53; BMFS5 |
| Size: | 20 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthetic phosphorylated peptide surrounding S392 of human p53 (NP_000537.3). |
| Swiss Prot. #: | P04637 |
| Calculated MW: | 53 kDa |
| Detected MW: | 53 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Vogelstein B and Kinzler KW, (1994) Nature 370, 174 - 175. 2. Levine AJ, (1997) Cell 88, 323 - 331. 3. Lu H, et al. (1997) Mol Cell Biol 17(10), 5923 - 5934. |
Details
P53 is a tumor suppressor that plays a role in maintaining genomic stability and controlling apoptosis. During the cell cycle, it can arrest cells at the G1/S checkpoint and activate DNA repair mechanisms. It is the most mutated gene in cancer. In unstressed cells, p53 usually exists at low levels in an inactive form, being bound to Mdm2. Phosphorylation of p53 at Ser392 is increased in human tumors and has been reported to influence the growth suppressor function, DNA binding, and transcriptional activation of p53.
