Additional Information
| Product Name: | MARCH6 Rabbit pAb |
|---|---|
| Catalog No.: | Y6322-100 |
| Also Known As: | MARCHF6; MARCH6; DOA10; MARCH-VI; RNF176; TEB4 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-80 of human MARCH6 (NP_005876.2). |
| Swiss Prot. #: | O60337 |
| Calculated MW: | 102 kDa |
| Detected MW: | 102 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Nagase T, et al. (1998) DNA Res 5, 31 - 39. 2. Hassink G, et al. (2005) Biochem J 388, 647 - 655. |
Details
MARCH6 is a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. MARCH6 promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Ubiquitination of type II deiodinase by MARCH6 is an important regulatory step in thyroid hormone signalling.
