Additional Information
| Product Name: | FBXW7 Rabbit pAb |
|---|---|
| Catalog No.: | Y5712-100 |
| Also Known As: | FBXW7; AGO; CDC4; FBW6; FBW7; FBX30; FBXO30; FBXW6; SEL10; hAgo; hCdc4 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 408-707 of human FBXW7 (NP_361014.1). |
| Swiss Prot. #: | Q969H0 |
| Calculated MW: | 79 kDa |
| Detected MW: | 79 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IF (1:50 - 1:200) IP (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Gupta - Rossi N, et al. (2001) J Biol Chem 276, 34371 - 34378. 2. Yada M, et al. (2004) EMBO J 23, 2116 - 2125. |
Details
FBXW7 is a member of the Fbws class of the F-box protein family. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complexes called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.
