Additional Information
| Product Name: | CYLD Rabbit pAb |
|---|---|
| Catalog No.: | Y9242-100 |
| Also Known As: | CYLD; BRSS; CDMT; CYLD1; CYLDI; EAC; MFT; MFT1; SBS; TEM; USPL2 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 654-953 of human CYLD (NP_001035877.1). |
| Swiss Prot. #: | Q9NQC7 |
| Calculated MW: | 107 kDa |
| Detected MW: | 107 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IP (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Brummelkamp TR, et al. (2003) Nature 424, 797 - 801. 2. Trompouki E, et al. (2003) Nature 424, 793 - 796. |
Details
CYLD is a member of the USP subfamily of DUBs. CYLD prefers to cleave lysine 63-linked or linear polyubiquitin chains. CYLD regulates inflammation and cell proliferation by down regulating NF-κB signaling through removal of ubiquitin chains from several NF-κB pathway proteins.
