Additional Information
| Product Name: | CSN8 Rabbit pAb |
|---|---|
| Catalog No.: | Y2772-100 |
| Also Known As: | COPS8; COP9; CSN8; SGN8 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human CSN8. |
| Swiss Prot. #: | Q99627 |
| Calculated MW: | 23 kDa |
| Detected MW: | 23 kDa |
| Applications: | WB (1:500 - 1:2,000) IF (1:50 - 1:200) IP (not tested) IHC (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Lykke - Andersen K and Wei N, (2003) Gene 321, 65 - 72. 2. Seeger M, et al. (1998) FASEB J 12, 469 - 478. 3. Bech - Otschir D, et al. (2001) EMBO J 20, 1630 - 1639. |
Details
CSN8 is a subunit of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ub ligase activity of SCF-type complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases.
