Additional Information
| Product Name: | CHIP Rabbit pAb |
|---|---|
| Catalog No.: | Y6232-100 |
| Also Known As: | STUB1; CHIP; HSPABP2; NY-CO-7; SCAR16; SDCCAG7; UBOX1 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CHIP (NP_005852.2). |
| Swiss Prot. #: | Q9UNE7 |
| Calculated MW: | 34 kDa |
| Detected MW: | 34 kDa |
| Applications: | WB (1:500 - 1:2,000) IF (1:50 - 1:200) IP (not tested) IHC (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. McDonough H and Patterson C, (2003) Cell Stress Chaperones 8, 303 - 308. 2. Murata S, et al. (2001) EMBO Rep 2, 1133 - 1138. |
Details
CHIP is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to the ubiquitin proteasome system. CHIP contains three 34-amino acid TPR (tetratricopeptide repeat) domains at its amino terminus and a carboxy-terminal U-box domain. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, while E3 ubiquitin ligase activity is confined to the U-box domain.
