Additional Information
| Product Name: | ANAPC10 Rabbit pAb |
|---|---|
| Catalog No.: | Y6382-100 |
| Also Known As: | ANAPC10; APC10; DOC1 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human ANAPC10 (NP_055700.2). |
| Swiss Prot. #: | Q9UM13 |
| Calculated MW: | 21 kDa |
| Detected MW: | 26 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:100) IP (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Grossberger R, et al. (1999) J Biol Chem 274, 14500 - 14507. 2. Wendt KS, et al. (2001) Nature Struct Biol 8, 784 - 788. |
Details
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin and triggers exit from mitosis by ubiquitinating cyclin B, the activating subunit of cyclin-dependent kinase-1.
