Additional Information
| Product Name: | Pepstatin A |
|---|---|
| Also Known As: | No |
| Catalog No.: | P1054-10 |
| Size: | 10 mg |
| CAS: | 26305-03-3 |
| Formula: | C34H63N5O9 |
| Molecular Weight: | 685.9 g/mol |
| Form: | Powder |
| Quality Assurance: | > 98% purity |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Umezawa H., et al. J. Antibiot. 1970, 23, 259. 2. Deiss L P., et al. EMBO J. 1996, 15, 3861. |
Details
Pepstatin A is an irreversible inhibitor of aspartic acid proteases, including pepsin, cathepsin D, cathepsin E, chymosin, and HIV proteases. It inhibits lysosomal proteases and autophagy. Typical working concentration is 1 µM.
Protease Inhibitor Stock Solution Preparation:
100X or 1000X stock solution preparation (after fully dissolved, aliquot to small volume, and store at -20 0C).
- Aprotinin (catalog # P1053): Dissolve 20 mg in 10 ml of water or PBS to get 2 mg/ml stock (1000X). Working concentration is 2 µg/ml.
- Leupeptin Hemisulfate (catalog # P1057): Dissolve 10 mg in 2.1 ml of DMSO or water to get 10 mM stock (1000X). Working concentration is 10 µM.
- Pepstatin A (catalog # P1054): Dissolve 5 mg in 7.3 ml of DMSO to get 1 mM stock (1000X). Working concentration is 1 µM.
- AEBSF HCl (catalog # P1056): Dissolve 10 mg in 0.416 ml of DMSO to get 100 mM stock (100X). Working concentration is 1mM.
- Bestatin (catalog # P1055): Dissolve 5 mg in 16.2 ml DMSO to get 1 mM stock (1000X). Working concentration is 1 µM.
- E-64D (catalog # P1051): Dissolve 5 mg in 1.4 ml DMSO to get 10 mM stock (1000X). Working concentration is 10 µM.
