Additional Information
| Product Name: | Pomalidomide (CC-4047) |
|---|---|
| Also Known As: | CC-4047; Actimid |
| Catalog No.: | F5220-50 |
| Size: | 50 mg |
| CAS: | 19171-19-8 |
| Formula: | C13H11N3O4 |
| Molecular Weight: | 273.24 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Dimopoulos M., et al. (2007) The New England Journal of Medicine, 357, 2123. 2. Lopez-Girona AEA., et al. (2012)Leukemia, 26, 2326. |
Details
Pomalidomide is a second generation immunomodulator, and a thalidomide analog. Pomalidomide is a ligand of the E3 ubiquitin ligase Cereblon (CRBN), and it is widely used in PROTAC design for targeting protein substrates to the ubiqitin ligase CUL4/CRBN for ubiquitination, leading to subsequent proteasomal degradation.
