Additional Information
| Product Name: | Bardoxolone Methyl (RTA402) |
|---|---|
| Also Known As: | RTA402, CDDO-methyl ester |
| Catalog No.: | F5250-10 |
| Size: | 10 mg |
| CAS: | 218600-53-4 |
| Formula: | C32H43NO4 |
| Molecular Weight: | 505.69 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light. |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1.Yates MS., et al. (2007) Mol Cancer Ther, 6, 154. 2. Wu J., et al. (2014) Toxicology, 318, 22. |
Details
Bardoxolone methyl (RTA402) is a potent Nrf2 transcription factor activator by targeting KEAP1 to prevent Nrf2 ubiquitination and degradation. It exhibits potent antioxidative and anti-inflammatory activities, currently under phase III clinical trials for multiple chronic kidney diseases. It also inhibits NFkappaB-mediated transcription.
