Additional Information
| Product Name: | AT-406 (SM-406) |
|---|---|
| Also Known As: | CAS# 1071992-99-8 |
| Catalog No.: | F7170-25 |
| Size: | 25 mg |
| Molecular Weight: | 561.71 g/mol |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| Quality Assurance: | >98% by HPLC and NMR |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
| PDF Data Sheet: | Download PDF datasheet， MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | No |
| Shipping Method: | Room temperature shipping |
| References: | 1. Cai Q., et al. (2011) J. Med. Chem. 54, 2714 2. Brunckhorst M. K., et al. (2012) Cancer Biol. Ther., 13, 804 |
Details
AT-406 (also called SM-406) is a potent Smac mimetic that inhibits the ubiquitin ligase activity of inhibitors of apoptosis proteins XIAP, cIAP1 and cIAP2 with Ki values of 66.4, 1.9 and 5.1 nM, respectively. AT-406 induces apoptosis of various human cancer cell lines.
