Additional Information
| Product Name: | XIAP Rabbit pAb [KO Validated] |
|---|---|
| Catalog No.: | Y6262-100 |
| Also Known As: | XIAP; API3; BIRC4; IAP-3; ILP1; MIHA; XLP2; hIAP-3; hIAP3 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XIAP (NP_001158.2). |
| Swiss Prot. #: | P98170 |
| Calculated MW: | 56 kDa |
| Detected MW: | 56 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:100) IF (1:50 - 1:100) IP (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Duckett CS, et al. (1996) EMBO J 15, 2685 - 2694. 2. Deveraux QL and Reed JC, (1999) Genes Dev 13, 239 - 252. 3. Latour S and Aguilar C, (2015) Semin Cell Dev Biol 39, 115 - 123. |
Details
XIAP is a member of the inhibitor of apoptosis family of proteins (IAP). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. XIAP has a capacity to block apoptosis by directly inhibiting certain caspases. In addition to its antiapoptotic function, XIAP is involved in a variety of signaling pathways and/or cellular responses through ubiquitylation or as a signal transducer for the Nod-like receptors NOD1 and NOD2, which play a role in innate immunity.
