Additional Information
| Product Name: | VX-765 |
|---|---|
| Also Known As: | N/A |
| Catalog No.: | F7120 |
| Size: | 5 mg |
| CAS: | 273404-37-8 |
| Formula: | C24H33ClN4O6 |
| Molecular Weight: | 509 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
| PDF Data Sheet: | Download PDF datasheet, MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Wannamaker W, et al. (2007) J Pharmacol Exp Ther 2007,321:509-516. 2. Doitsh G, et al. (2014) Nature 2014,505:509-514. |
Details
VX-765 is an orally absorbed prodrug of VRT-043198, a potent and selective inhibitor of caspase-1 and 4. In cultures of peripheral blood mononuclear cells stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1β and IL-18, but had no affect the secretion of other cytokines including IL-α, TNFα, IL-6 and IL-8
