Additional Information
| Product Name: | VHL Rabbit pAb |
|---|---|
| Catalog No.: | Y6172-100 |
| Also Known As: | VHL; HRCA1; RCA1; VHL1; pVHL; PVHL |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Mouse, Rat |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VHL (NP_937799.1). |
| Swiss Prot. #: | P40337 |
| Calculated MW: | 24 kDa |
| Detected MW: | 24 kDa |
| Applications: | WB (1:500 - 1:2,000) IF (1:50 - 1:200) IP (not tested) IHC (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Latif F, et al. (1993) Science 260, 1317 - 1320. 2. Maxwell PH, et al. (1999) Nature 399, 271 - 275. |
Details
VHL is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen.
