Additional Information
| Product Name: | Torin-1 |
|---|---|
| Also Known As: | 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Catalog No.: | F6100 |
| Size: | 5 mg |
| Molecular Weight: | 607.62 Da |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| Quality Assurance: | >99% by HPLC and NMR |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
| PDF Data Sheet: | PDF Datasheet, MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Guertin DA, et al. (2009) Sci.Signal. 2(67):pe24 2. Thoreen CC, et al. (2009) J.Biol.Chem. 284(12):8023-32 3. Liu Q, et al. (2010) J.Med.Chem. 53(19):7146-55 |
Details
Torin 1-is a cell permeable highly potent, selective and ATP-competitive mTOR inhibitor of the mammalian target of rapamycin (mTOR) kinase. Torin-1 exhibits over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, as well as 450 other protein kinases. Torin-1 has been found to impair cell growth and proliferation through a mechanism involving mTORC1 inhibition other than mTORC2 inhibition, in which the rapamycin-resistant functions of mTORC1 is suppressed..
How to use
Torin-1 was used at 2-5,000 nM in cell-balsed in vitro assays.
Torin-1 was used at 2-5,000 nM in cell-balsed in vitro assays.
