Additional Information
| Product Name: | SBI-0206965 |
|---|---|
| Also Known As: | 2-(5-bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yloxy)-N-methylbenzamide |
| Catalog No.: | F6211 |
| Size: | 25 mg |
| CAS: | 1884220-36-3 |
| Formula: | C21H21BrN4O5 |
| Molecular Weight: | 489.32 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
| PDF Data Sheet: | Download PDF datasheet， MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | Egan, DF, et al. (2015) Mol Cell 59 285-297. |
Details
SBI-0206965 is a potent inhibitor of the autophagy kinase ULK1. It inhibits ULK1 and ULK2 kinases with IC₅₀ of 108 nM and 711 nM, respectively. ULK1 is a serine/threonine kinase acting upsteam of PI3K to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation. SBI-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival.
Solubility:
10 mg/ml in DMSO
Solubility:
10 mg/ml in DMSO
