Additional Information
| Product Name: | 6xHis-ISG15 |
|---|---|
| Also Known As: | G1P2; IP17; UCRP; IFI15; hUCRP |
| Catalog No.: | E2100 |
| Size: | 500 µg |
| Molecular Weight: | 17.9 kDa |
| Species: | Human |
| Source: | Bacterial recombinant |
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Concentration: | See tube label |
| Quality Assurance: | ~95% by SDS-PAGE, see datasheet for gel image |
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| NCBI RefSeq: | NM_005101 |
| Image(s): | No |
| Shipping Method: | Dry ice shipping |
| References: | 1. D’Cunha J, et al. (1996) Proc Natl Acad Sci USA 93(1), 211 – 215. 2. D’Cunha J, et al. (1996) J Immunol 157(9), 4100 – 4108. 3. Zhang D, et al. (2011) J Interferon Cytokine Res 21 (1), 119 – 130. |
Details
Interferon – stimulated gene 15 (Isg15) is a 15 kDa Ub – like protein. It is linked to proteins in much the same way as Ub, using the E1, E2, E3 cascade. U bE1L and UbcH8 are the specific E1 and E2, respectively, to mediate protein ISGylation. Several E3s have also been found. Isg15 is induced by type I interferons (IFNα/β) and bacterial and viral infections. Studies are still being conducted to discover the biological functions of Isg15.
