Additional Information
| Product Name: | VE-821 |
|---|---|
| Also Known As: | 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide |
| Catalog No.: | F8131 |
| Size: | 25 mg |
| CAS: | 1232410-49-9 |
| Formula: | C18H16N4O3S |
| Molecular Weight: | 368.41 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
| PDF Data Sheet: | Download PDF datasheet， MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | 1. Reaper PM, et al. (2011) Nat Chem Biol, 7(7), 428-430. 2. Prevo, R, et al. (2012) Cancer Biol Ther, 13(11) 1072-1081. 3. Huntoon, CJ, et al. (2013) Cancer Res, 73(12) 3683-3691. |
Details
VE-821 is a potent and selective ATP competitive inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) with IC50 of 26 nM in cell-free assays, with minimal activity against ATM, DNA-PK, and mTOR. It augments DNA damage and cell death of cancer cells in response to radiation, also sensitizes cancer cells to chemotherapy.
Solubility:
20 mg/ml in DMSO
Solubility:
20 mg/ml in DMSO
