Additional Information
| Product Name: | Pifithrin-alpha |
|---|---|
| Also Known As: | Pifithrin-α, Ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1) |
| Catalog No.: | F7160 |
| Size: | 5 mg |
| CAS: | 63208-82-2 |
| Formula: | C16H18N2OS.HBr |
| Molecular Weight: | 367.3 g/mol |
| Form: | Lyophilized powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
| PDF Data Sheet: | Download PDF datasheet， MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | Komarov, PG, et al. (1999) Science 285, 1733-1737 |
Details
Pifithrin-alpha is an inhibitor of p53, reversibly inhibits p53-dependent transactivation of p53-responsive genes and apoptosis. Pifithrin-α (10 μM) enhances cell survival after genotoxic stress such as UV irradiation and treatment with DNA damage compounds including doxorubicin, etopoxide, and paclitaxel.
Solubility:
20 mg/ml in DMSO
Working Condition:
10 μM
Solubility:
20 mg/ml in DMSO
Working Condition:
10 μM
