Additional Information
| Product Name: | CHIR-99021 HCl |
|---|---|
| Also Known As: | 6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino)ethylamino)nicotinonitrile hydrochloride |
| Catalog No.: | F6191 |
| Size: | 25 mg |
| CAS: | 252917-06-9 |
| Formula: | C22H18Cl2N8.HCl |
| Molecular Weight: | 501.8 g/mol |
| Form: | Powder |
| Quality Assurance: | >98% by HPLC and NMR |
| Source: | Synthetic |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
| PDF Data Sheet: | Download PDF datasheet， MSDS |
| Image(s): | N/A |
| Shipping Method: | Room temperature shipping |
| References: | Ring DB, et al. (2003) Diabetes 52(3), 588-595. |
Details
CHIR-99021 (CT99021) is an inhibitor of GSK-3α/β with IC50 of 10 nM/6.7 nM, respectively. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells.
Solubility:
> 20 mg/ml in DMSO
Solubility:
> 20 mg/ml in DMSO
