Additional Information
| Product Name: | GST-RNF4 | ||
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| Also Known As: | SLX5; SNURF; RES4-26 | ||
| Catalog No.: | K1100 | ||
| Size: | 50 µg | ||
| Molecular Weight: | 21.3 kDa | ||
| Species: | Human | ||
| Source: | Bacterial recombinant | ||
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol | ||
| Concentration: | See tube label | ||
| Quality Assurance: | ~90% by SDS-PAGE, see datasheet for gel image | ||
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles | ||
| PDF Data Sheet: | PDF Datasheet， MSDS | ||
| NCBI RefSeq: | NM_001185009 | ||
| Image(s): | (Click image to enlarge)
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| Shipping Method: | Dry ice shipping | ||
| References: | 1. Chiariotti L, et al. (1998) Genomics 47(2), 258 – 265. 2. Fedele M, et al. (2000) J Biol Chem 275(11), 7894 – 7901. 3. Hunter T, Sun H (2008) Ernst Schering Found Sump Proc (1), 1 – 16. 4. Tatham MH, et al. (2008) Nat Cell BIol 10(5), 538 – 546. 5. Bruderer R, et al. (2011) EMBO Rep 12(2), 142 – 148. |
Details
RING-finger 4 (RNF4), also known as Snurf, is an E3 ubiquitin ligase. RNF4 is composed of four SUMO interaction motifs (SIMs) at the N-terminal and a RING domain at the C-terminal. The SIM domains prefer binding polySUMO chains; RNF4 functions to ubiquitinate polysumolyated proteins including promyelocytic leukaemia (PML), which target them for proteasomal degradation.
Images:
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified GST-RNF4 |
