Additional Information
| Product Name: | UCHL1 |
|---|---|
| Also Known As: | PARK5; PGP95; PGP9.5; Uch-L1; PGP 9.5 |
| Catalog No.: | H1100 |
| Size: | 25 µg |
| Molecular Weight: | 24.8 kDa |
| Species: | Human |
| Source: | Bacterial recombinant |
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Concentration: | See tube label |
| Quality Assurance: | ~95% by SDS-PAGE, see datasheet for gel image |
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| NCBI RefSeq: | NM_004181 |
| Image(s): |  Coomassie stained SDS-PAGE |
| Shipping Method: | Dry ice shipping |
| References: | 1. Pickart CM, et al. (1985) J Biol Chem 260(13), 7903 – 7910. 2. Wilkinson KD (1997) FASEB J 11(14), 1245 – 1256. 3. Larsen CN, et al. (1998) Biochemistry 37(10), 3358 – 3368. 4. Reyes-Turcu FE, et al. (2009) Annu Rev Biochem 78, 363 – 397. |
Details
Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. UCHL1 is one of the four members of the ubiquitin C-terminal hydrolase (UCH) family. It is thought to be mainly involved in cleaving proubiquitin proteins into monomeric ubiquitin.
