Additional Information
| Product Name: | OTUB2 |
|---|---|
| Also Known As: | OTB2; OTU2; C14orf137 |
| Catalog No.: | H3101 |
| Size: | 100 µg |
| Molecular Weight: | 27.2 kDa |
| Species: | Human |
| Source: | Bacterial recombinant |
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Concentration: | See tube label |
| Quality Assurance: | ~95% by SDS-PAGE, see datasheet for gel image |
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| NCBI RefSeq: | NM_023112 |
| Image(s): |  Coomassie stained SDS-PAGE |
| Shipping Method: | Dry ice shipping |
| References: | 1. Balakirev MY, et al. (2003) EMBO Rep 4(5), 517 – 522. 2. Reyes-Turcu FE, et al. (2009) Annu Rev Biochem 78, 363 – 397. 3. Li S, et al. (2010) J Biol Chem 285(7), 4291 – 4297. |
Details
Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB2 is a member of the ovarian tumor domain family. Not much is known about the biological function of this enzyme, but it may deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.
