Additional Information
| Product Name: | GST-UCHL3 |
|---|---|
| Also Known As: | GST-UCH-L3 |
| Catalog No.: | H1210 |
| Size: | 25 µg |
| Molecular Weight: | 26.2 kDa |
| Species: | Human |
| Source: | Bacterial recombinant |
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Concentration: | See tube label |
| Quality Assurance: | ~95% by SDS-PAGE, see datasheet for gel image |
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| NCBI RefSeq: | NM_001270952 |
| Image(s): |  Coomassie stained SDS-PAGE Lane 1: Marker Lane 2: UCHL3 Lane 3: GST-UCHL3 |
| Shipping Method: | Dry ice shipping |
| References: | 1. Pckard CM, Rose IA (1985) J Biol Chem 260(13), 7903 – 7910. 2. Day IN, et al. (1990) Biochem J 268(2), 521 – 524. 3. Wilkinson KD, et al. (1999) J Mol Biol 291(5), 1067 – 1077. 4. Kwon J (2007) Exp Anim 56(2), 71 – 77. |
Details
Ubiquitin C-terminal hydrolase L3 (UchL3) is a deubiquitinase enzyme (DUB), which performs hydrolysis of the bond at the C terminus of the ubiquitin and trims down the polyubiquitin chain into monomers. UchL3 has been found to also process a ubiquitin-like substrate called NEDD8. It is 52% identical to the amino acid sequence of its related DUB, UchL1, and may share roles in maintaining neurons of the gracile tract in mice.
