Additional Information
| Product Name: | USP21 Rabbit pAb |
|---|---|
| Catalog No.: | Y9602-100 |
| Also Known As: | USP21; USP16; USP23 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human USP21 (NP_001014443.1). |
| Swiss Prot. #: | Q9UK80 |
| Calculated MW: | 62 kDa |
| Detected MW: | 62 kDa |
| Applications: | WB (1:500 - 1:2,000) IP (not tested) IHC (not tested) IF (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Smith TS and Southan C, (2000) Biochim Biophys Acta 1490, 184 - 188. 2. Nakagawa T, et al. (2008) Genes Dev 22, 37 - 49. |
Details
USP21 is a member of the USP subfamily of DUBs. DUBs are categorized into 5 subfamilies: USP, UCH, OTU, MJD, and JAMM. USP21 deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation.
