Additional Information
| Product Name: | Rpn4 Rabbit mAb |
|---|---|
| Catalog No.: | Y2332-100 |
| Also Known As: | PSMD9; Rpn4; p27 |
| Size: | 100 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-223 of human Rpn2. |
| Swiss Prot. #: | O00233 |
| Calculated MW: | 24 kDa |
| Detected MW: | 24 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IF (1:50 - 1:200) IP (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Watanabe TK, et al. (1998) Genomics 50, 241 - 250. 2. Kaneko T, et al. (2009) Cell 137, 914 - 925. |
Details
Rpn4 is a chaperone protein for the assembly of the 19S regulatory complex (PA700). During the base subcomplex assembly it is part of an intermediate Rpn4:Rpt4:Rpt5 module. Rpn4 is released during the further base assembly process. Rpn4 was first characterized as a component of the PA700 proteasomal regulator, and was found to stimulate association of PA700 with the catalytic20S proteasome to form the active 26S proteasome.
