Additional Information
| Product Name: | PSMB8 Rabbit pAb |
|---|---|
| Catalog No.: | Y2172-20 |
| Also Known As: | PSMB8; ALDD; D6S216; D6S216E; JMP; LMP7; NKJO; PSMB5i; RING10 |
| Size: | 20 µl |
| Concentration: | See labels on tube |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 163-272 of human PSMB8. |
| Swiss Prot. #: | P28062 |
| Calculated MW: | 30 kDa |
| Detected MW: | 23-28 kDa |
| Applications: | WB (1:500 - 1:2,000) IHC (1:50 - 1:200) IF (1:50 - 1:200) IP (not tested) Note: Antibody dilution should be optimized by users. |
| Purification: | Protein A or G affinity purification |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Storage: | Store at -20℃. Centrifuge to maximize product recovery. |
| PDF Data Sheet: | PDF Datasheet， MSDS |
| Image(s): | (Click image to enlarge)  |
| Shipping Method: | Wet ice shipping |
| References: | 1. Agarwal AK, et al. (2010) Am J Hum Genet 87, 866 - 872. 2. Tomko RJ and Hochstrasser M, (2013) Annu Rev Biochem 82, 415 - 45. |
Details
Proteasome subunit beta 5i (PSMB8) is one of the inducible beta subunits of the immuno 20S proteasome that catalyzes "chymotrypsin-like" activity by cleaving after large hydrophobic residuess of polypeptides. The 20S proteasome has a barrel-like structure containing four stacked αββα rings. Each α or β ring is composed of seven different proteins. β1, β2 and β5 have peptidase activities that hydrolyze proteins. The corresponding catalytic subunits in immunoproteasomes are β1i, β2i and β5i subunits. The 20S proteasome can assemble with other protein complexes that activate the 20S proteasome to degrade proteins.
